ABSTRACT
OBJECTIVE: Aim of the study was to observe the clinicohaematological profile, bone marrow and serum iron indices of patients with chronic renal failure. METHOD: A total of 27 patients of chronic renal failure were selected, irrespective of their age, sex, clinical profile and etiology. These patients were not on dialysis, haematinics or erythropoietin therapy. They underwent series of biochemical and haematological investigation including bone marrow aspiration and also estimation of serum iron indices. RESULTS: The commonest cause of chronic renal failure in study group was diabetes mellitus (20%), glomerulonephritis (8%). Fifty percent of the patients on first presentation were in end-stage renal disease. Most patients presented with features of anaemia (94%), uraemia (63%) and fluid overload (96%). Severity of anaemia was correlating with degree of azotemia. Sixty percent of the patients had microcytic hypochromic anaemia, five percent had macrocytic anaemia while 30% had normocytic normochromic anaemia. The reticulocyte count was high in 46% of the patients. RDW-CV of greater than 14 was observed in 67%. Thrombocytopaenia was found in 52% of the patients. Leucocyte count was within normal range in 75%. In differential leucocyte count and absolute eosinophil count was high in 32% of the subject. In bone marrow examination 61% of the patients had normal bone marrow cellularity, 75% were having erythroid hyperplasia. Fifty seven percent of the cases had bone marrow iron store of zero, 37.8% had normal bone marrow iron store, 6.5% had increased bone marrow iron store. Serum ferritin was low in 62% and serum iron was below normal in 74% of the patients. CONCLUSION: Majority (65%) of patient had microcytic hypochronic anaemia because of iron deficiency and 33% of patient had parasitic infestation.
Subject(s)
Adolescent , Adult , Aged , Anemia, Iron-Deficiency/etiology , Anemia, Macrocytic/etiology , Bone Marrow Examination , Child , Diabetes Complications , Female , Glomerular Filtration Rate , Glomerulonephritis/complications , Humans , Iron/blood , Kidney Failure, Chronic/blood , Leukocyte Count , Male , Middle AgedABSTRACT
El presente trabajo prospectivo, se realizó en el Hospital Maternidad de Lima con 1000 gestantes, las cuales constituyeron el Grupo I del estudio. Entre los meses de Abril a Setiembre de 1985 acudieron a control prenatal y se les hizo análisis hematológicos, evaluándose sus niveles de hemoglobina y factores asociados con la anemia. La hemoglobina promedio en el total de gestantes fué de 10.8 gr. por ciento, el 29 por ciento tuvo hemoglobina menor de 10 gr. por ciento y de éstas, se estudiaron 70, que tenían Hb menor de 9 grs. por ciento, las cuales constituyeron el Grupo II del estudio. La asociación entre la anemia con la edad gestacional, multiparidad y período internatal corto, tuvo significación estadística. Se encontró un 87.2 por ciento de anemias hipocrómicas y un 10 por ciento de macrocíticas
Subject(s)
Pregnancy , Anemia/diagnosis , Anemia/physiopathology , Peru , Hemoglobins , Gestational Age , Erythropoiesis , Anemia, Hypochromic/etiology , Anemia, Macrocytic/etiology , HemodilutionABSTRACT
Megaloblastic anemia following gastrectomy is due to the total absence or inadequate secretion of intrinsic factor and is manifested by megalobastic changes in bone marrow, blood cells, and other proliferative cells. In Korea, detailed description and precise analyses of the cases of megaloblastic anemia following gastrectomy are relatively rare in contrast to the potential of its incidence from gastrectomy due to many causes or to the importance of its clinical significance. Here, we present the case of a 51-year old man who had undergone a total gastrectomy with esophagojejunostomy and incidental splenectomy due to early gastric cancer and developed megalobastic anemla 7 years after surgery. After gradual improvement of clinical and hematologic features with treatment of parenteral vltamin Bl2, he was followed-up with vitamin B12 maintenance therapy.